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Saturday, May 18 2013 @ 11:46 AM CDT

Gastrointestinal system
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This is a submucosal spindle cell lesion composed of bland cells with no mitotic figures and no necrosis or apoptosis. the cells are positive for CD34 and Vimentin only. The differential diagnosis is that of inflammaroy myofibroblastic tumor (young people usually and CD34 negative) and GIST (CD117 and DOG-1 positive). Note the numerous eosinophils and chronic inflammatory cells.
Inflammatory Fibroid Polyp of the Stomach
Thursday, September 06 2012 @ 11:43 AM CDT
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Bad tumor. Special stains: for zymogen granules are PAS positive and diastase resistant. Immunostains: Trypsin and Chymotrypsin positive and often may show Chromogranin A and Synaptophisine positivity.
Acinar Cell Carcinoma of the Pancreas
Monday, March 19 2012 @ 10:37 AM CDT
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Primary biliary cirrhosis (PBC) is a chronic and progressive cholestatic disease of the liver.Primary biliary cirrhosis is most frequently a disease of women and occurs between the fourth and sixth decades of life. The symptoms may strongly affect patients' quality of life and may induce incapacitation.
Biliary Cirrhosis
Tuesday, April 05 2011 @ 09:11 AM CDT
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This tumor is positive for HepPar-1, AFP (not sensitive but specific), and MOC31 negative (note: MOC31 is positive in cholangiocarcinoma and metastatic carcinomas)
Hepatocellular carcinoma
Thursday, December 30 2010 @ 09:56 AM CST
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Niemann-Pick disease is inherited in an autosomal recessive pattern, which means both copies, or alleles, of the gene must be mutated (altered in such a way that function is impaired, in contrast to a polymorphism, in which the nucleotide sequence is altered but causes no functional disruption) for a person to be affected by the disorder. Most often, the parents of a child with an autosomal recessive disorder are not affected but are carriers of one copy of the altered gene. If both parents are carriers, there is a 25% chance with each pregnancy for an affected child. The condition can be classified as follows: * Niemann-Pick disease, SMPD1-associated, which includes types A and B * Niemann-Pick disease, type C, which includes types C1 and C2. (Type D is caused by the same gene as type C1.)
Niemann-Pick
Wednesday, December 15 2010 @ 01:23 PM CST
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Congenital hepatic fibrosis is an inherited fibrocystic liver disease associated with proliferation of interlobular bile ducts within the portal areas and fibrosis that do not alter hepatic lobular architecture.Embryogenically, CHF is due to malformation of the duct plate, a round structure appearing in the eighth week of gestation that is formed by primitive hepatocytes, which differentiate into cholangiocytes.
Congenital hepatic fibrosis
Wednesday, December 15 2010 @ 01:23 PM CST
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Undifferentiated gastric carcinoma with lymphoid stroma is a histological type of gastric cancer with favorable prognosis, microscopically characterized by nests of high grade neoplastic epithelial cells intermingled with a dense lymphoid proliferation. These are usually positve for EBV .
Undifferentiated lymphoepithelioma-like gastric carcinoma (Medullary carcinoma of stomach)
Tuesday, March 02 2010 @ 07:44 AM CST
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Alpha 1-antitrypsin deficiency (?1-antitrypsin deficiency, A1AD or simply Alpha-1) is a genetic disorder caused by defective production of alpha 1-antitrypsin (A1AT), leading to decreased A1AT activity in the blood and lungs, and deposition of excessive abnormal A1AT protein in liver cells. Lecture: http://www.youtube.com/watch?v=YxB04tGvqd0
Alpha-1-antitrypsin deficiency
Friday, November 13 2009 @ 09:24 AM CST
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Solid-pseudopapillary tumors of the pancreas (SPTs) are uncommon tumors, constituting only 1% of pancreatic neoplasms. SPTs are neoplasms of young women and are frequently grossly sharply circumscribed and cystic lesions (although their microscopic margins may be indistinct). Most importantly, despite their often large size (mean of >10 cm at presentation in one study), the vast majority of SPTs are indolent neoplasms. The neoplastic epithelial cells are uniform, polygonal, and discohesive in nature. Frequent degenerative changes in larger tumors, however, lend a characteristic pseudopapillary pattern because of residual epithelial cells that form perivascular rosettes. SPTs are known to consistently express vimentin, a-1-anti-trypsin, neuron-specific enolase, progesterone receptors, and more recently, CD10.
Solid Pseudopapillary Neoplasm of the Pancreas
Friday, November 13 2009 @ 09:18 AM CST
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These pancreatic tumors exhibit acinar differentiation and comprising less than 2% of these neoplasms. The overall survival is very poor with a medial survival approximately 16 to 20 months. ACC may arise in any portion of the pancreas. Most are large with approximate size of 10 cm in diameter. The acinar pattern shows multiple lumina with basally located nuclei and moderate amounts of eosinophilic granular apical cytoplasm. The solid pattern if present lacks lumen formation but may show basal palisading of the nuclei interface of the solid nests within the stroma. Occasionally cystic change and nodule nodular growth pattern and intraductal growth has been documented. The nuclei are relatively uniform oval with a central single nucleolus. There are easily detectable numerous mitotic figures. Zymogen cytoplasmic granules are positive on PAS stain and are resistant to diastase digestion. Immunohistochemical stains for the enzymes tripsin and chimotrypsin are very sensitive in detecting acinar differentiation. Differential diagnosis includes pancreatic endocrine tumors, pancreatoblastoma or solid papillary neoplasm as well also well differentiated adenocarcinoma.
Acinar Cell Carcinoma of the Pancreas
Friday, November 13 2009 @ 09:10 AM CST
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CCS is a rare disorder that was originally described by Leonard Wolsey Cronkhite Jr., an internist, and Wilma Jeanne Canada, a radiologist, in 1955. The syndrome is characterized by abnormalities of the gastrointestinal mucosal surfaces and the skin, together with clinical features of severe protein-losing malnutrition, gastrointestinal blood loss and the secondary effects of these. GI Tract: The stomach and colon are the most commonly involved sites, as well as the duodenum and distal ileum. The mucosal abnormalities are caused by expansions of the lamina propria, primarily be edema, but also inflammatory cells and macrophages. The epithelium is distorted and pits or crypts are cystically dilated. This expanded lamina propria may form polyps or nodular elevations, or may result in diffusely enlarged gastric or intestinal folds. To some, these polyps resemble juvenile polyps, and this disorder has been grouped with the hamartomatous polyposis syndromes Skin: Alopecia involving scalp, eyebrows, face and eventually complete hair loss is some patients. Onychodystrophic changes include thinning, splitting, onycholysis (partial separation of nail from bed), and onychomadesis (loss of finger and toenails). Hyperpigmentation in the form of pigmented macules and plaques on the hands and arms and elsewhere is the third cutaneous abnormality that may be seen. About 75% of the reported affected patients are Japanese, and the remainder European or North American. There are no know familial occurrences, and the etiology is not known.
Cronkhite-Canada Syndrome
Friday, May 08 2009 @ 03:17 PM CDT
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Peritoneal mesothelioma is a rare disease. The incidence is approximately one per 1,000,000 and about one fifth to one third of all mesotheliomas are peritoneal.The architectural features of the peritoneal mesothelioma may be quite heterogeneous including
Peritoneal Mesothelioma
Saturday, August 02 2008 @ 05:08 PM CDT
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