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Wednesday, May 22 2013 @ 03:56 PM CDT

Hematopathology
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Castleman's disease (CD, angiofollicular lymph node hyperplasia) is a lymphoproliferative disorder associated in a subset of cases with the human immunodeficiency virus (HIV) and human herpesvirus 8 (HHV-8). CD comprises at least two distinct diseases (localized and multicentric) with very different prognoses. - The hyaline vascular variant is characterized by the presence of abnormal follicles with atrophic or "regressed" germinal centers surrounded by broad mantle zones of small lymphocytes, which are often present in an "onion-skin" arrangement. (shown above) - The plasma cell variant has hyperplastic germinal centers and often some regressed or "hyaline vascular" follicles as well; the interfollicular region is hypervascular and contains sheets of plasma cells. - HHV8+ Castleman's disease is characterized by preservation of nodal architecture and increased numbers of follicles that vary from hyperplastic to regressed. The interfollicular region contains proliferating blood vessels and mature plasma cells, similar to the plasma cell type. In contrast to the localized HHV8-negative plasma cell variant, in HHV8+ CD increased numbers of immunoblasts (called plasmablasts in some reports) are present in the outer mantle zones of the hyperplastic follicles and sometimes in the germinal centers as well source UpToDate.
Castleman's disease
Thursday, October 04 2012 @ 10:38 AM CDT
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Type A - epithelial cells have an oval or fusiform shape (less lymphocyte count); Type B - an epithelioid cells: B1 -Lymphocyte-rich B2 - Cortical B3 - Epithelial Type AB - tumor contains a combination of A and B.
Thymoma, type B1
Thursday, August 16 2012 @ 11:52 AM CDT
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Phagocytosis by macrophages of erythrocytes, leukocytes, platelets, and their precursors in bone marrow and other tissues. This is a clinical syndrome than can be associated with a variety of underlying conditions leading to the same characteristic hyperinflammatory phenotype with hypercytokinemia and excessive activation of lymphocytes and macrophages. It is seen in association with viral and malignant diseases.
Hemophagocytic Syndrome
Tuesday, April 05 2011 @ 09:05 AM CDT
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Lymphomatoid granulomatosis (LYG) is a rare Epstein-Barr virus–associated systemic angiodestructive lymphoproliferative disease. It is characterized by prominent pulmonary involvement but can also involve multiple extrapulmonary sites. =============== T
Lymphomatoid Granulomatosis
Saturday, August 02 2008 @ 05:18 PM CDT
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Lymphomatoid granulomatosis (LYG) is a rare Epstein-Barr virus–associated systemic angiodestructive lymphoproliferative disease. It is characterized by prominent pulmonary involvement but can also involve multiple extrapulmonary sites. ===============
Lymphomatoid Granulomatosis
Saturday, August 02 2008 @ 05:18 PM CDT
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Gaucher disease is an inherited metabolic disorder in which harmful quantities of a fatty substance called glucocerebroside accumulate in the spleen, liver, lungs, bone marrow, and sometimes in the brain. There are three types of Gaucher disease. The firs
Gaucher Disease
Saturday, August 02 2008 @ 05:18 PM CDT
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The patient has metastatic ductal carcinoma of the breast.
Erythrophagocytosis
Wednesday, November 16 2005 @ 02:53 PM CST
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Follicular lymphomas are one of the more common non-Hodgkin's lymphomas in North America. They afflict almost exclusively adults, particularly the middle-aged and elderly. Because the small-cleaved cells of follicular lymphomas know how to circulate in th
Follicular Center Cell Lymphoma
Wednesday, October 26 2005 @ 03:54 PM CDT
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Organization of focal hemorrhages giving rise to foci of fibrosis containing deposits of iron and calcium salts encrusted on connective tissue and elastic fibers. These lesions are found in patients with portal vein or splenic vein thrombosis, hemolyti
Gamna-Gandy bodies (Spleen)
Thursday, October 13 2005 @ 03:17 PM CDT
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Peripheral blood smear from the patient on total parenteral nutrition (TPN). TPN is a risk factor for the infection with M. furfur from the normally colonized skin. M.furfur is important to culture on the olive (oillong chain fatty acids) reach substrate
Malassezia Furfur
Saturday, August 02 2008 @ 05:17 PM CDT
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Numerous small to medium sized lymphocytes, some with deeply cleaved nuclei, characteristic for centrocytes.
Periferal Blood Folicular Lymphoma
Saturday, August 02 2008 @ 05:17 PM CDT
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Systemic Candida infection
Saturday, August 02 2008 @ 05:17 PM CDT
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